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Ribosomal protein L7
Symbols RPL7; MGC117326; humL7-1; LOC653702
External IDs OMIM: 604166HomoloGene87772
RNA expression pattern

More reference expression data

Human Mouse
Entrez 6129 n/a
Ensembl ENSG00000147604 n/a
Uniprot P18124 n/a
Refseq NM_000971 (mRNA)
NP_000962 (protein)
n/a (mRNA)
Location Chr 8: 74.37 - 74.37 Mb n/a
Pubmedsearch [1] n/a

Ribosomal protein L7, also known as RPL7, is a human gene.[1]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[1]