Response to Primate Clones Alarming - Sent Using Google Toolbar

Response to Primate Clones Alarming

Response to Primate Clones Alarming

On November 14, 2007, the online version of the journal Nature featured an article by Oregon researchers lead by Shoukhrat Mitalipov at the Oregon National Primate Research Center and the Oregon Stem Cell Center, Oregon Health and Science University, describing how they were able to clone embryos from adult macaque monkeys using a new technique that prevents damage to the eggs during handling.

What was alarming to me, were the responses of several leading scientists, as quoted in a report describing the work in The Independent online edition. The scientists are quoted as saying that the "marvellous work….should provide the basis for attempts at cloning human embryos" and that the work is significant because it suggests that cloning in primates and humans may not be as difficult as previously thought. I wonder though: Should we even dare to discuss that possibility? I thought that at least nearly everyone agreed that the cloning of human embryos was a taboo subject, and it alarms me to hear that there might stsill be a significant number of people who think it's an endeavour we should pursue.

Read the article: "Producing primate embryonic stem cells by somatic cell nuclear transfer".

Coverage in The Independent: "UK experts hail cloning breakthrough".

Tell us what you think:


More Drugmaker Growth Without the FDA - Sent Using Google Toolbar

More Drugmaker Growth Without the FDA

Having freed myself from a life of sitting at a bench doing experiments, I now continue my list of laboratory supply companies that should grow as the health-care sector grows. They've got potential to grow as fast as the health-care sector without having to deal with clinical trial results.

Earlier this week I wrote an article that discussed companies that provide valuable research supplies to laboratories. In today's article I'll concentrate on those that supply equipment to the labs. As with the last group, this is a list of companies to check out because they're providing good equipment that I know scientists buy, but it's not a ringing endorsement to buy the stocks. I'll leave the due diligence up to you.

One theme you'll see is that, in addition to selling equipment, the companies also sell the consumables, which are used up and need to be bought again and again, that work in their machines. In some cases -- like PCR machines -- consumables are readily available from multiple sources, but in many cases the companies have designed the equipment to work only with their consumables. That means that placement of machines drives consumable product sales, and investors just need to keep track of placement rates to get an idea of where future sales are headed.

Organic chemistry - Wikipedia, the free encyclopedia

Organic chemistry - Wikipedia, the free encyclopedia: "

Organic chemistry · Chemistry

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Organic chemistry is a specific discipline within chemistry which involves the scientific study of the structure, properties, composition, reactions, and preparation (by synthesis or by other means) of chemical compounds consisting primarily of carbon and hydrogen, which may contain any number of other elements, including nitrogen, oxygen, halogens as well as phosphorus, silicon and sulfur.[1][2] [3]

The original definition of "organic" chemistry came from the misconception that organic compounds were always related to life processes. Not all organic compounds support life on Earth, but life as we know it also depends heavily on inorganic chemistry; for example, many enzymes rely on transition metals such as iron and copper; and materials such as shells, teeth and bones are part organic, part inorganic in composition. Apart from elemental carbon, inorganic chemistry deals only with simple carbon compounds, with molecular structures which do not contain carbon to carbon connections (its oxides, acids, carbonates, carbides, and minerals). This does not mean that single-carbon organic compounds do not exist (viz. methane and its simple derivatives). Biochemistry mainly deals with the chemistry of proteins (and other large biomolecules).

Because of their unique properties, multi-carbon compounds exhibit extremely large variety and the range of application of organic compounds is enormous. They form the basis of, or are important constituents of many products (paints, plastics, food, explosives, drugs, petrochemicals, to name but a few) and (apart from a very few exceptions) they form the basis of all life processes.

The different shapes and chemical reactivities of organic molecules provide an astonishing variety of functions, like those of enzyme catalysts in biochemical reactions of live systems. The autopropagating nature of these organic chemicals is what life is all about.

Trends in organic chemistry include chiral synthesis, green chemistry, microwave chemistry, fullerenes and microwave spectroscopy.



[edit] Historical highlights

See also: History of chemistry

At the beginning of the nineteenth century chemists generally thought that compounds from living organisms were too complicated in structure to be capable of artificial synthesis from non-living things, and that a 'vital force' or vitalism conferred the characteristics of living beings on this form of matter. They named these compounds 'organic', and preferred to direct their investigations toward inorganic materials that seemed more promising.

Organic chemistry received a boost when it was realized that these compounds could be treated in ways similar to inorganic compounds and could be created in the laboratory by means other than 'vital force'. Around 1816 Michel Chevreul started a study of soaps made from various fats and alkali. He separated the different acids that, in combination with the alkali, produced the soap. Since these were all individual compounds, he demonstrated that it was possible to make a chemical change in various fats (which traditionally come from organic sources), producing new compounds, without 'vital force'. In 1828 Friedrich Wöhler first manufactured the organic chemical urea (carbamide), a constituent of urine, from the inorganic ammonium cyanate NH4OCN, in what is now called the Wöhler synthesis. Although Wöhler was, at this time as well as afterwards, cautious about claiming that he had thereby destroyed the theory of vital force, most have looked to this event as the turning point.

A great next step was when in 1856 William Henry Perkin, while trying to manufacture quinine, again accidentally came to manufacture the organic dye now called Perkin's mauve, which by generating a huge amount of money greatly increased interest in organic chemistry. Another step was the laboratory preparation of DDT by Othmer Zeidler in 1874, but the insecticide properties of this compound were not discovered until much later.

The crucial breakthrough for the theory of organic chemistry was the concept of chemical structure, developed independently and simultaneously by Friedrich August Kekule and Archibald Scott Couper in 1858. Both men suggested that tetravalent carbon atoms could link to each other to form a carbon lattice, and that the detailed patterns of atomic bonding could be discerned by skillful interpretations of appropriate chemical reactions.

The history of organic chemistry continues with the discovery of petroleum and its separation into fractions according to boiling ranges. The conversion of different compound types or individual compounds by various chemical processes created the petroleum chemistry leading to the birth of the petrochemical industry, which successfully manufactured artificial rubbers, the various organic adhesives, the property-modifying petroleum additives, and plastics.

The pharmaceutical industry began in the last decade of the 19th century when acetylsalicylic acid (more commonly referred to as aspirin) manufacture was started in Germany by Bayer. The first time a drug was systematically improved was with arsphenamine (Salvarsan). Numerous derivatives of the dangerously toxic atoxyl were systematically synthesized and tested by Paul Ehrlich and his group, and the compound with best effectiveness and toxicity characteristics was selected for production.

Early examples of organic reactions and applications were serendipitous, such as Perkin's accidental discovery of Perkin's mauve. However, from the 20th century, the progress of organic chemistry allowed for synthesis of specifically selected compounds or even molecules designed with specific properties, as in drug design. The process of finding new synthesis routes for a given compounds is called total synthesis. Total synthesis of complex natural compounds started with urea, increased in complexity to glucose and terpineol, and in 1907, total synthesis was commercialized the first time by Gustaf Komppa with camphor. Pharmaceutical benefits have been substantial, for example cholesterol-related compounds have opened ways to synthesis of complex human hormones and their modified derivatives. Since the start of the 20th century, complexity of total syntheses has been increasing, with examples such as lysergic acid and vitamin B12. Today's targets feature tens of stereogenic centers that must be synthesized correctly with asymmetric synthesis.

Biochemistry, the chemistry of living organisms, their structure and interactions in vitro and inside living systems, has only started in the 20th century, opening up a brand new chapter of organic chemistry with enormous scope.

[edit] Classification of organic substances

[edit] Description and nomenclature

Classification is not possible without having a full description of the individual compounds. In contrast with inorganic chemistry, in which describing a chemical compound can be achieved by simply enumerating the chemical symbols of the elements present in the compound together with the number of these elements in the molecule, in organic chemistry the relative arrangement of the atoms within a molecule must be added for a full description.

One way of describing the molecule is by drawing its structural formula. Because of molecular complexity, simplified systems of chemical notation have been developed. The latest version is the line-angle formula, which achieves simplicity without introducing ambiguity. In this system, the endpoints and intersections of each line represent one carbon, and hydrogens can either be notated or assumed to be present by implication. Some disadvantages of chemical notation are that they are not easily described by words and they are not easily printable. These problems have been addressed by describing molecular structures using organic nomenclature .

Because of the difficulties arising from the very large number and variety of organic compounds, chemists realized early on that the establishment of an internationally accepted system of naming organic compounds was of paramount importance. The Geneva Nomenclature was born in 1892 as a result of a number of international meetings on the subject.

It was also realized that as the family of organic compounds grew, the system would have to be expanded and modified. This task was ultimately taken on by the International Union on Pure and Applied Chemistry (IUPAC). Recognizing the fact that in the branch of biochemistry the complexity of organic structures increases, the IUPAC organization joined forces with the International Union of Biochemistry and Molecular Biology, IUBMB, to produce a list of joint recommendations on nomenclature.

Later, as the numbers and complexities of organic molecules grew, new recommendations were made within IUPAC for simplification. The first such recommendation was presented in 1951 when a cyclic benzene structure was named a cyclophane. Later recommendations extended the method to the simplification of other complex cyclic structures, including heterocyclics, and named such structures phanes.

For ordinary communication, to spare a tedious description, the official IUPAC naming recommendations are not always followed in practice except when it is necessary to give a concise definition to a compound, or when the IUPAC name is simpler (viz. ethanol versus ethyl alcohol). Otherwise the common or trivial name may be used, often derived from the source of the compound.

In summary, organic substances are classified by their molecular structural arrangement and by what other atoms are present along with the chief (carbon) constituent in their makeup, whilst in a structural formula, hydrogen is implicitly assumed to occupy all free valences of an appropriate carbon atom which remain after accounting for branching, other element(s) and/or multiple bonding.

[edit] Hydrocarbons and functional groups

The family of carboxylic acids contains a carboxyl (-COOH) functional group. Acetic acid is an example.
The family of carboxylic acids contains a carboxyl (-COOH) functional group. Acetic acid is an example.

Classification normally starts with the hydrocarbons: compounds which contain only carbon and hydrogen. For sub-classes see below. Other elements present themselves in atomic configurations called functional groups which have decisive influence on the chemical and physical characteristics of the compound; thus those containing the same atomic formations have similar characteristics, which may be: miscibility with water, acidity/alkalinity, chemical reactivity, oxidation resistance, and others. Some functional groups are also radicals, similar to those in inorganic chemistry, defined as polar atomic configurations which pass during chemical reactions from one chemical compound into another without change.

Some of the elements of the functional groups (O, S, N, halogens) may stand alone and the group name is not strictly appropriate, but because of their decisive effect on the way they modify the characteristics of the hydrocarbons in which they are present they are classed with the functional groups, and their specific effect on the properties lends excellent means for characterisation and classification.

Referring to the hydrocarbon types below, many, if not all of the functional groups which are typically present within aliphatic compounds are also represented within the aromatic and alicyclic group of compounds, unless they are dehydrated, which would lead to non-reacting co-optional groups.

Reference is made here again to the organic nomenclature, which shows an extensive (if not comprehensive) number of classes of compounds according to the presence of various functional groups, based on the IUPAC recommendations, but also some based on trivial names. Putting compounds in sub-classes becomes more difficult when more than one functional group is present.

Two overarching chain type categories exist: Open Chain aliphatic compounds and Closed Chain cyclic compounds. Those in which both open chain and cyclic parts are present are normally classed with the latter.

[edit] Aliphatic compounds

The aliphatic hydrocarbons are subdivided into three groups, homologous series according to their state of saturation: paraffins alkanes without any double or triple bonds, olefins alkenes with double bonds, which can be mono-olefins with a single double bond, di-olefins, or di-enes with two, or poly-olefins with more. The third group with a triple bond is named after the name of the shortest member of the homologue series as the acetylenes alkynes. The rest of the group is classed according to the functional groups present.

From another aspect aliphatics can be straight chain or branched chain compounds, and the degree of branching also affects characteristics, like octane number or cetane number in petroleum chemistry.

[edit] Aromatic and alicyclic compounds

Benzene is one of the best-known aromatic compounds
Benzene is one of the best-known aromatic compounds

Cyclic compounds can, again, be saturated or unsaturated. Because of the bonding angle of carbon, the most stable configurations contain six carbon atoms, but while rings with five carbon atoms are also frequent, others are rarer. The cyclic hydrocarbons divide into alicyclics and aromatics (also called arenes).

Of the alicyclic compounds the cycloalkanes do not contain multiple bonds, whilst the cycloalkenes and the cycloalkynes do. Typically this latter type only exists in the form of large rings, called macrocycles. The simplest member of the cycloalkane family is the three-membered cyclopropane.

Aromatic hydrocarbons contain conjugated double bonds. One of the simplest examples of these is benzene, the structure of which was formulated by Kekulé who first proposed the delocalization or resonance principle for explaining its structure. For "conventional" cyclic compounds, aromaticity is conferred by the presence of 4n + 2 delocalized pi electrons, where n is an integer. Particular instability (antiaromaticity) is conferred by the presence of 4n conjugated pi electrons.

The characteristics of the cyclic hydrocarbons are again altered if heteroatoms are present, which can exist as either substituents attached externally to the ring (exocyclic) or as a member of the ring itself (endocyclic). In the case of the latter, the ring is termed a heterocycle. Pyridine and furan are examples of aromatic heterocycles while piperidine and tetrahydrofuran are the corresponding alicyclic heterocycles. The heteroatom of heterocyclic molecules is generally oxygen, sulfur, or nitrogen, with the latter being particularly common in biochemical systems.

Rings can fuse with other rings on an edge to give polycyclic compounds. The purine nucleoside bases are notable polycyclic aromatic heterocycles. Rings can also fuse on a "corner" such that one atom (almost always carbon) has two bonds going to one ring and two to another. Such compounds are termed spiro and are important in a number of natural products.

[edit] Polymers

This swimming board is made of polystyrene, an example of a polymer
This swimming board is made of polystyrene, an example of a polymer

One important property of carbon in organic chemistry is that it can form certain compounds, the individual molecules of which are capable of attaching themselves to one another, thereby forming a chain or a network. The process is called polymerization and the chains or networks polymers, while the source compound is a monomer. Two main groups of polymers exist: those artificially manufactured are referred to as industrial polymers [4] or synthetic polymers and those naturally occurring as biopolymers.

Since the invention of the first artificial polymer, bakelite, the family has quickly grown with the invention of others. Common synthetic organic polymers are polyethylene or polythene, polypropylene, nylon, teflon or PTFE, polystyrene, polyesters, polymethylmethacrylate (commonly known as perspex or plexiglas) polyvinylchloride or PVC, and polyisobutylene important artificial or synthetic rubber also the polymerised butadiene, a rubber component.

The examples are generic terms, and many varieties of each of these may exist, with their physical characteristics fine tuned for a specific use. Changing the conditions of polymerisation changes the chemical composition of the product by altering chain length, or branching, or the tacticity. With a single monomer as a start the product is a homopolymer. Further, secondary component(s) may be added to create a heteropolymer (co-polymer) and the degree of clustering of the different components can also be controlled. Physical characteristics, such as hardness, density, mechanical or tensile strength, abrasion resistance, heat resistance, transparency, colour, etc. will depend on the final composition.

[edit] Biomolecules

Maitotoxin, a complex organic biological toxin.
Maitotoxin, a complex organic biological toxin.

Biomolecular chemistry is a major category within organic chemistry which is frequently studied by biochemists. Many complex multi-functional group molecules are important in living organisms. Some are long-chain biopolymers, and these include proteins, DNA, RNA and the polysaccharides such as starches in animals and celluloses in plants. The other main classes are amino acids (monomer building blocks of proteins), carbohydrates (which includes the polysaccharides), the nucleic acids (which include DNA and RNA as polymers), and the lipids. In addition, animal biochemistry contains many small molecule intermediates which assist in energy production through the Krebs cycle, and produces isoprene, the most common hydrocarbon in animals. Isoprenes in animals form the important steroid structural (cholesterol) and steroid hormone compounds; and in plants form terpenes, terpenoids, some alkaloids, and a unique set of structural hydrocarbons called biopolymer polyisoprenoids present in latex sap which is the basis for making rubber.

[edit] Others

Organic compounds containing bonds of carbon to nitrogen, oxygen and the halogens are not normally grouped separately. Others are sometimes put into major groups within organic chemistry and discussed under titles such as organosulfur chemistry, organometallic chemistry, organophosphorus chemistry and organosilicon chemistry.

[edit] Characteristics of organic substances

The structure of methane by pictorial representation of a Lewis diagram showing the sharing of electronpairs between atomic nuclei in a covalent  bond.  Please do not form the impression from the diagram that the real picture is two-dimensional, because this is not the case.
The structure of methane by pictorial representation of a Lewis diagram showing the sharing of electronpairs between atomic nuclei in a covalent bond. Please do not form the impression from the diagram that the real picture is two-dimensional, because this is not the case.

Organic compounds are generally covalently bonded. This allows for unique structures such as long carbon chains and rings. The reason carbon is excellent at forming unique structures and that there are so many carbon compounds is that carbon atoms form very stable covalent bonds with one another (catenation). In contrast to inorganic materials, organic compounds typically melt, boil, sublimate, or decompose below 300 °C. Neutral organic compounds tend to be less soluble in water compared to many inorganic salts, with the exception of certain compounds such as ionic organic compounds and low molecular weight alcohols and carboxylic acids where hydrogen bonding occurs.

Organic compounds tend to dissolve in organic solvents which are either pure substances like ether or ethyl alcohol, or mixtures, such as the paraffinic solvents such as the various petroleum ethers and white spirits, or the range of pure or mixed aromatic solvents obtained from petroleum or tar fractions by physical separation or by chemical conversion. Solubility in the different solvents depends upon the solvent type and on the functional groups if present. Solutions are studied by the science of physical chemistry. Like inorganic salts, organic compounds may also form crystals. A unique property of carbon in organic compounds is that its valency does not always have to be taken up by atoms of other elements, and when it is not, a condition termed unsaturation results. In such cases we talk about carbon carbon double bonds or triple bonds. Double bonds alternating with single in a chain are called conjugated double bonds. An aromatic structure is a special case in which the conjugated chain is a closed ring.

[edit] Molecular structure elucidation

Molecular models of caffeine
Molecular models of caffeine

Organic compounds consist of carbon atoms, hydrogen atoms, and functional groups. The valence of carbon is 4, and hydrogen is 1, functional groups are generally 1. From the number of carbon atoms and hydrogen atoms in a molecule the degree of unsaturation can be obtained. Many, but not all structures can be envisioned by the simple valence rule that there will be one bond for each valence number. The knowledge of the chemical formula for an organic compound is not sufficient information because many isomers can exist. Organic compounds often exist as mixtures. Because many organic compounds have relatively low boiling points and/or dissolve easily in organic solvents there exist many methods for separating mixtures into pure constituents that are specific to organic chemistry such as distillation, crystallization and chromatography techniques. There exist several methods for deducing the structure an organic compound. In general usage are (in alphabetical order):

  • Crystallography: This is the most precise method for determining molecular geometry; however, it is very difficult to grow crystals of sufficient size and high quality to get a clear picture, so it remains a secondary form of analysis. Crystallography has seen especially extensive use in biochemistry (for protein structure determination) and in the characterization of organometallic catalysts, which often possess significant symmetry.
  • Elemental analysis: A destructive method used to determine the elemental composition of a molecule. See also mass spectrometry, below.
  • Infrared spectroscopy: Chiefly used to determine the presence (or absence) of certain functional groups.
  • Mass spectrometry: Used to determine the molecular weight of a compound and from the fragmentation pattern its structure. High resolution mass spectrometry can often identify the precise formula of a compound through knowledge of isotopic masses and abundances; it is thus sometimes used in lieu of elemental analysis.
  • Nuclear magnetic resonance (NMR) spectrometry identifies different nuclei based on their chemical environment. This is the most important and commonly used spectroscopic technique for organic chemists, often permitting complete assignment of atom connectivity and even stereochemistry given the proper set of spectroscopy experiments (e.g. correlation spectroscopy).
  • Optical rotation: Distinguishes between two enantiomers of a chiral compound based on the sign of rotation of plane polarized light. If the specific rotation of an enantiomer is known, the magnitude of rotation also gives the ratio of enantiomers in a mixed sample, though HPLC with a chiral column also can supply this information.
  • UV/VIS spectroscopy: Used to determine degree of conjugation in the system. While still sometimes used to characterize molecules, UV/VIS is more commonly used to quantitate how much of a known compound is present in a (typically liquid) sample.

Additional methods are provided by analytical chemistry.

[edit] Organic reactions

Organic reactions are chemical reactions involving organic compounds. While pure hydrocarbons undergo certain limited classes of reactions, many more reactions which organic compounds undergo are largely determined by functional groups. The general theory of these reactions involves careful analysis of such properties as the electron affinity of key atoms, bond strengths and steric hindrance. These issues can determine the relative stability of short-lived reactive intermediates, which usually directly determine the path of the reaction. An example of a common reaction is a substitution reaction written as:

Nu + C-X → C-Nu + X

where X is some functional group and Nu is a nucleophile.

There are many important aspects of a specific reaction. Whether it will occur spontaneously or not is determined by the Gibbs free energy change of the reaction. The heat that is either produced or needed by the reaction is found from the total enthalpy change. Other concerns include whether side reactions occur from the same reaction conditions. Any side reactions which occur typically produce undesired compounds which may be anywhere from very easy or very difficult to separate from the desired compound.

[edit] See also

[edit] References

  1. ^ Robert T. Morrison, Robert N. Boyd, and Robert K. Boyd, Organic Chemistry, 6th edition (Benjamin Cummings, 1992, ISBN 0-13-643669-2) - this is "Morrison and Boyd", a classic textbook
  2. ^ John D. Roberts, Marjorie C. Caserio, Basic Principles of Organic Chemistry,(W. A. Benjamin,Inc.,1964) - another classic textbook
  3. ^ Richard F. and Sally J. Daley, Organic Chemistry, Online organic chemistry textbook. http://www.ochem4free.info
  4. ^ "industrial polymers, chemistry of." Encyclopædia Britannica. 2006

[edit] External links

At Wikiversity you can learn more and teach others about Organic chemistry at:
Wikibooks has more on the topic of


Questions reportedly asked in the Patent Bar Exam - Patentbarquestions

Questions reportedly asked in the Patent Bar Exam - Patentbarquestions: ""

Computer Adaptive Test Prep - Practice Exams, Testing Software, Accurate Score Assessments

Computer Adaptive Test Prep - Practice Exams, Testing Software, Accurate Score Assessments: "

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