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Understanding Genetics: DNA, Genes, and Their Real-World Applications

Understanding Genetics: DNA, Genes, and Their Real-World Applications
(24 lectures, 30 minutes/lecture)
Course No. 1533

Taught by David Sadava
The Claremont McKenna, Pitzer, and Scripps Colleges
Ph.D., University of California at San Diego

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We use it routinely to cure diseases, solve crimes, and reunite families. Yet we've known about it for only 60 years. And what we're continuing to learn about it every day has the potential to transform our health, our nutrition, our society, and our future. What is this powerful mystery?

It is DNA—deoxyribonucleic acid, the self-replicating material present in nearly all living organisms. Award-winning teacher, author, and cancer researcher Dr. David Sadava unlocks its mysteries in his new course, Understanding Genetics: DNA, Genes, and Their Real-World Applications. He guides us through decades of scientific discovery and the weighty implications for us, as individuals and as a society.

Genetics: The Science of Heredity

How are the traits of an organism—be it a fern or a human father—passed on to its offspring? This course outlines the history of the science of genetics and explains in detail what we have learned in recent decades about the building blocks—DNA.

Dr. Sadava, a working scientist who draws on examples from his own research, shows us how understanding genetics allows us to improve medical treatment and nutrition, vastly improving our health and quality of life.

Understanding genetics is also a critical step toward understanding our human identity. Examining our DNA—how it works and what happens when something goes wrong—enables us to see the roots of how our bodies work, why we get sick, and how traits are passed through families.

Enjoy this rare opportunity to peer over the shoulder of a working scientist; learn how he puzzles through the problems of genetics to find meaningful solutions that can save lives. Dr. Sadava shares cutting-edge research guided by his passion to help laypeople understand the meaning and importance of genetics.

Genetics' Long and Fascinating History

Our understanding of human development has certainly evolved since ancient Greek times, when Aristotle thought that the ingredients in semen were reorganized by menstrual fluid during intercourse to produce an embryo. And as late as the 17th century, Antonie Van Leeuwenhoek thought he saw tiny, fully formed babies when he looked under a microscope at sperm.

Other past civilizations, however, knew more about genetics than we might think. For example, Egyptians successfully bred the date palm 4,000 years ago to improve the quality and quantity of their fruit crop. In Asia and the Near East 3,500 years ago, horses were bred for speed in racing.

But while humans have worked to improve plant and animal characteristics for thousands of years, we've only come to truly understand what genes are made of and how they work during the past century.

Insight into a Puzzle

Understanding genetics is like sitting down to work a massive puzzle. With each piece you examine, think through, and solve, you glean a new and amazing insight into humanity. Put several pieces together, and you can treat or cure a disease, save a developing fetus from a fatal birth defect, catch a criminal, or reunite a family.

DNA, genes, proteins, amino acids, and enzymes are the vocabulary of our being—what goes on inside our bodies and how our genes are expressed. To learn this vocabulary is to be conversant in who we are and what we can become.

To help us understand the role of proteins in DNA, Professor Sadava cites the example of boiling an egg. A protein's shape is sensitive to its surroundings and can be changed by heat. When you boil an egg—made of a protein called albumin—the heat of the water changes the albumin's structure to create a completely different consistency. As Professor Sadava reminds us, "You can't unboil an egg; changes are irreversible." Next time you're making egg salad, just think—you've transformed a protein!

Dr. Sadava loves to tell tales, and the stories he uses to introduce each lecture are the highlight of the course. He weaves in history, true crime, case studies of people with life-threatening diseases, and phenomena from the natural world to make genetics come to life. Then he steadfastly supports each story with explanatory science.

Professor Sadava deftly introduces us to the puzzle that is genetics, and shows how unlocking each piece helps solve significant real-world problems that affect everyone.

Each lecture begins with a helpful story that illustrates the importance of genetics. The course explicitly outlines the connections between the science of genetics and the health-related problems that plague us in modern society, and illuminates how studying genetics can be instrumental in solving those problems.

While Understanding Genetics is a vigorous and briskly paced course, you won't need a background in biology or chemistry. You'll feel challenged, but you won't be left behind. Professor Sadava is passionate about his subject and extremely knowledgeable.

Genetics in the News

Should we allow cloning? How can we treat obesity? Why do different ethnic groups have higher rates of particular diseases than others? Countless questions of biology prompt heated discussions in the classroom, the legislature, and the courtroom. Obtaining a basic and current knowledge of how genetics works helps inform our ideas and opinions on these important issues.

Many of us are touched by diseases caused by genetic mutations or flaws—such as cystic fibrosis, diabetes, cancer, and sickle cell anemia. In the face of life-threatening, debilitating diseases, Professor Sadava gives us hope through research and discoveries made every day in the field of genetics.

He tells the story of one couple whose young son had cystic fibrosis, the most common inherited disease. Genetic testing prior to their next pregnancy enabled them to implant an embryo without the cystic fibrosis genes into the mother's uterus. The result: the couple was able to have a healthy daughter.

Only in the past few decades have scientists begun to discover and isolate the particular genes that cause certain diseases or conditions and to conduct the research that enables us to actually change genetics.

As Professor Sadava reminds us throughout the course, genetics is not destiny. How we grow and develop is strongly influenced by our environment. But understanding genetics provides us with a wealth of information that can help improve the health and quality of life for everyone.

Should I Buy Audio or Video?

This course works well in both audio and video. The DVD version includes more than 800 on-screen elements, including text, 3-D animations, photographs, and illustrations.

History of chemistry - Wikipedia, the free encyclopedia

History of chemistry - Wikipedia, the free encyclopedia

History of chemistry

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Pliny the Elder: an imaginative 19th Century portrait. No contemporary depiction of Pliny has survived.
Pliny the Elder: an imaginative 19th Century portrait. No contemporary depiction of Pliny has survived.
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The history of chemistry is long and convoluted. It begins with the discovery of fire, then metallurgy which allowed purification of metals and the making of alloys, as well as the exploitation of many minerals and natural substances. Much of the early development of purification methods is described by Pliny the Elder in his Naturalis Historia. He made attempts to explain those methods, as well as making acute observations of the state of many minerals.

He was followed by attempts to explain the nature of matter and its transformations through the protoscience of alchemy, then the development of a scientific method by Geber, and then refutations of alchemy by several Arabic chemists. Modern chemistry begins to emerge when the distinction is made between chemistry and alchemy by Robert Boyle in his work The Sceptical Chymist (1661). Chemistry then becomes a full-fledged science when Antoine Lavoisier develops his law of conservation of mass, which demands careful measurements and quantitative observations of chemical phenomena. So, while both alchemy and chemistry are concerned with the nature of matter and its transformations, it is only the chemists who apply the scientific method.The history of chemistry is intertwined with the history of thermodynamics, especially through the work of Willard Gibbs.



[edit] The discovery of fire and atomism

The roots of chemistry can be traced to the phenomenon of burning.[citation needed] Fire was a mystical force that was said to transform one substance into another, and was thus an object of wonder and superstition. Fire affected many aspects of early societies, such as their diet, because it allowed them to cook food, and make pottery, specialised tools and utensils.

Atomism can be traced back to ancient Greece and ancient India.[citation needed] Greek atomism dates back to 440 BCE, as what might be indicated by the book De Rerum Natura (The Nature of Things)[1] written by the Roman Lucretius[2] in 50 BCE. In the book was found ideas traced back to Democritus and Leucippus, who declared that atoms were the most indivisible part of matter. This coincided with a similar declaration by Indian philosopher Kanada in his Vaisheshika sutras around the same time period.[3] Kashyapa may have arrived at his sutras by meditation. By similar means discussed the existence of gases. What Kanada declared by sutra, Democritus declared by philosophical musing. Both suffered from a lack of empirical data. Without scientific proof, the existence of atoms was easy to deny. Aristotle opposed the existence of atoms in 330 BC; and the atomism of the Vaisheshika school was also opposed for a long time.[citation needed]

In Europe, the Church raised Aristotle's writings almost to the level of scripture, associating atomism as some form of heresy. Aristotle's writings were preserved in Arabic in the Muslim world, and were later translated to Latin by St. Thomas Aquinas and alchemist Roger Bacon in the 13th century.

[edit] The rise of metallurgy

It was fire that led to the discovery of glass and the purification of metals which in turn gave way to the rise of metallurgy.[citation needed] During the early stages of metallurgy, methods of purification of metals were sought, and gold, known in ancient Egypt as early as 2600 BCE, became a precious metal. The discovery of alloys heralded the Bronze Age. After the Bronze Age, the history of metallurgy was marked by which army had better weaponry. Countries in Eurasia had their heyday when they made the superior alloys, which, in turn, made better armour and better weapons. This often determined the outcomes of battles.[citation needed]

[edit] Indian metallurgy and alchemy

Significant progress in metallurgy and alchemy was made in ancient India. Will Durant wrote in The Story of Civilization I: Our Oriental Heritage:

"Something has been said about the chemical excellence of cast iron in ancient India, and about the high industrial development of the Gupta times, when India was looked to, even by Imperial Rome, as the most skilled of the nations in such chemical industries as dyeing, tanning, soap-making, glass and cement... By the sixth century the Hindus were far ahead of Europe in industrial chemistry; they were masters of calcinations, distillation, sublimation, steaming, fixation, the production of light without heat, the mixing of anesthetic and soporific powders, and the preparation of metallic salts, compounds and alloys. The tempering of steel was brought in ancient India to a perfection unknown in Europe till our own times; King Porus is said to have selected, as a specially valuable gift from Alexander, not gold or silver, but thirty pounds of steel. The Moslems took much of this Hindu chemical science and industry to the Near East and Europe; the secret of manufacturing "Damascus" blades, for example, was taken by the Arabs from the Persians, and by the Persians from India."

[edit] The philosopher's stone and the rise of alchemy

Main article: Alchemy

Many people were interested in finding a method that could convert cheaper metals into gold. The material that would help them do this was rumored to exist in what was called the philosopher's stone. This led to the protoscience called alchemy. Alchemy was practiced by many cultures throughout history and often contained a mixture of philosophy, mysticism, and protoscience.[citation needed]

Alchemy not only sought to turn base metals into gold, but especially in a Europe rocked by bubonic plague, there was hope that alchemy would lead to the development of medicines to improve people's health. The holy grail of this strain of alchemy was in the attempts made at finding the elixir of life, which promised eternal youth. Neither the elixir nor the philosopher's stone were ever found. Also, characteristic of alchemists was the belief that there was in the air an "ether" which breathed life into living things.[citation needed] Practitioners of alchemy included Isaac Newton, who remained one throughout his life.

[edit] Problems encountered with alchemy

There were several problems with alchemy, as seen from today's standpoint. There was no systematic naming system for new compounds, and the language was esoteric and vague to the point that the terminologies meant different things to different people. In fact, according to The Fontana History of Chemistry (Brock, 1992):

The language of alchemy soon developed an arcane and secretive technical vocabulary designed to conceal information from the uninitiated. To a large degree, this language is incomprehensible to us today, though it is apparent that readers of Geoffery Chaucer's Canon's Yeoman's Tale or audiences of Ben Jonson's The Alchemist were able to construe it sufficiently to laugh at it.[4]

Chaucer's tale exposed the more fraudulent side of alchemy, especially the manufacture of counterfeit gold from cheap substances. Soon after Chaucer, Dante Alighieri also demonstrated an awareness of this fraudulence, causing him to consign all alchemists to the Inferno in his writings. Soon after, in 1317, the Avignon Pope John XXII ordered all alchemists to leave France for making counterfeit money. A law was passed in England in 1403 which made the "multiplication of metals" punishable by death. Despite these and other apparently extreme measures, alchemy did not die. Royalty and privileged classes still sought to discover the philosopher's stone and the elixir of life for themselves.[5]

There was also no agreed-upon scientific method for making experiments reproducible. Indeed many alchemists included in their methods irrelevant information such as the timing of the tides or the phases of the moon. The esoteric nature and codified vocabulary of alchemy appeared to be more useful in concealing the fact that they could not be sure of very much at all. As early as the 14th century, cracks seemed to grow in the facade of alchemy; and people became sceptical.[citation needed] Clearly, there needed to be a scientific method where experiments can be repeated by other people, and results needed to be reported in a clear language that laid out both what is known and unknown.

[edit] From Alchemy to Chemistry

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[edit] Early chemists

See also: Alchemy (Islam)

The development of the modern scientific method was slow and arduous, but an early scientific method for chemistry began emerging among early Muslim chemists, beginning with the 9th century chemist Geber, who is "considered by many to be the father of chemistry".[6][7][8][9] He invented and named the alembic (al-anbiq), chemically analyzed many chemical substances, composed lapidaries, distinguished between alkalis and acids, and manufactured hundreds of drugs.[10] Among other influential Muslim chemists, Ja'far al-Sadiq[11] and Rhazes[12] criticized Aristotle's theory of four classical elements; Alkindus,[13] Abū al-Rayhān al-Bīrūnī,[14] Avicenna[15] and Ibn Khaldun refuted the practice of alchemy and the theory of the transmutation of metals; and Tusi described an early version of the conservation of mass, noting that a body of matter is able to change but is not able to disappear.[16] For the more honest practitioners in Europe, alchemy was an intellectual pursuit, and over time, they got better at it. Paracelsus (1493-1541), for example, rejected the 4-elemental theory and with only a vague understanding of his chemicals and medicines, formed a hybrid of alchemy and science in what was to be called iatrochemistry. Paracelsus was not perfect in making his experiments truly scientific. For example, as an extension of his theory that new compounds could be made by combining mercury with sulfur, he once made what he thought was "oil of sulfur". This was actually dimethyl ether, which had neither mercury nor sulfur.[citation needed]

Robert Boyle, one of the co-founders of modern chemistry through his use of proper experimentation, which further separated chemistry from alchemy
Robert Boyle, one of the co-founders of modern chemistry through his use of proper experimentation, which further separated chemistry from alchemy

Robert Boyle (1627–1691) is considered to have refined the modern scientific method for alchemy and to have separated chemistry further from alchemy.[citation needed] Robert Boyle was an atomist, but favoured the word corpuscle over atoms. He comments that the finest division of matter where the properties are retained is at the level of corpuscles.

Boyle was credited with the discovery of Boyle's Law. He is also credited for his landmark publication The Sceptical Chymist, where he attempts to develop an atomic theory of matter, with no small degree of success. Despite all these advances, the person celebrated as the "father of modern chemistry" is Antoine Lavoisier who developed his law of Conservation of mass in 1789, also called Lavoisier's Law.[citation needed] With this, Chemistry was allowed to have a strict quantitative nature, allowing reliable predictions to be made.

[edit] Antoine Lavoisier

Portrait of Monsieur Lavoisier and his Wife, by Jacques-Louis David
Portrait of Monsieur Lavoisier and his Wife, by Jacques-Louis David

Although the archives of chemical research draw upon work from ancient Babylonia, Egypt, and especially the Arabs and Persians after Islam, modern chemistry flourished from the time of Antoine Lavoisier, who is regarded as the "father of modern chemistry", particularly for his discovery of the law of conservation of mass, and his refutation of the phlogiston theory of combustion in 1783. (Phlogiston was supposed to be an imponderable substance liberated by flammable materials in burning.) Mikhail Lomonosov independently established a tradition of chemistry in Russia in the 18th century.[citation needed] Lomonosov also rejected the phlogiston theory, and anticipated the kinetic theory of gases.[citation needed] He regarded heat as a form of motion, and stated the idea of conservation of matter.

[edit] The vitalism debate and organic chemistry

After the nature of combustion (see oxygen) was settled, another dispute, about vitalism and the essential distinction between organic and inorganic substances, was revolutionized by Friedrich Wöhler's accidental synthesis of urea from inorganic substances in 1828. Never before had an organic compound been synthesized from inorganic material.[citation needed] This opened a new research field in chemistry, and by the end of the 19th century, scientists were able to synthesize hundreds of organic compounds. The most important among them are mauve, magenta, and other synthetic dyes, as well as the widely used drug aspirin. The discovery also contributed greatly to the theory of isomerism.[citation needed]

[edit] Disputes about atomism after Lavoisier

Bust of Dalton by Chantrey
Bust of Dalton by Chantrey

Throughout the 19th century, chemistry was divided between those who followed the atomic theory of John Dalton and those who did not, such as Wilhelm Ostwald and Ernst Mach.[17] Although such proponents of the atomic theory as Amedeo Avogadro and Ludwig Boltzmann made great advances in explaining the behavior of gases, this dispute was not finally settled until Jean Perrin's experimental investigation of Einstein's atomic explanation of Brownian motion in the first decade of the 20th century.[17]

Well before the dispute had been settled, many had already applied the concept of atomism to chemistry. A major example was the ion theory of Svante Arrhenius which anticipated ideas about atomic substructure that did not fully develop until the 20th century. Michael Faraday was another early worker, whose major contribution to chemistry was electrochemistry, in which (among other things) a certain quantity of electricity during electrolysis or electrodeposition of metals was shown to be associated with certain quantities of chemical elements, and fixed quantities of the elements therefore with each other, in specific ratios.[citation needed] These findings, like those of Dalton's combining ratios, were early clues to the atomic nature of matter.

[edit] The periodic table

For many decades, the list of known chemical elements had been steadily increasing. A great breakthrough in making sense of this long list (as well as, eventually, in understanding the internal structure of atoms as discussed below) was Dmitri Mendeleev and Lothar Meyer's development of the periodic table, and, particularly, Mendeleev's use of it to predict the existence and the properties of germanium, gallium, and scandium, which Mendeleev called ekasilicon, ekaaluminium, and ekaboron respectively. Mendeleev made his prediction in 1870; gallium was discovered in 1875, and was found to have roughly the same properties that Mendeleev predicted for it.[citation needed]

[edit] The modern definition of chemistry

Classically, before the 20th century, chemistry was defined as the science of the nature of matter and its transformations. It was therefore clearly distinct from physics which was not concerned with such dramatic transformation of matter. Moreover, in contrast to physics, chemistry was not using much of mathematics. Even some were particularly reluctant to using mathematics within chemistry. For example, Auguste Comte wrote in 1830:

Every attempt to employ mathematical methods in the study of chemical questions must be considered profoundly irrational and contrary to the spirit of chemistry.... if mathematical analysis should ever hold a prominent place in chemistry -- an aberration which is happily almost impossible -- it would occasion a rapid and widespread degeneration of that science.

However, in the second part of the 19th century, the situation changed and August Kekule wrote in 1867:

I rather expect that we shall someday find a mathematico-mechanical explanation for what we now call atoms which will render an account of their properties.

After the discovery by Ernest Rutherford and Niels Bohr of the atomic structure in 1912, and by Marie and Pierre Curie of radioactivity, scientists had to change drastically their viewpoint on the nature of matter. The experience acquired by chemists was no longer pertinent to the study of the whole nature of matter but only to aspects related to the electron cloud surrounding the atomic nuclei and the movement of the latter in the electric field induced by the former (see Born-Oppenheimer approximation). The range of chemistry was thus restricted to the nature of matter around us in conditions which are not too far from standard conditions for temperature and pressure and in cases where the exposure to radiation is not too different from the natural microwave, visible or UV radiations on Earth. Chemistry was therefore re-defined as the science of matter that deals with the composition, structure, and properties of substances and with the transformations that they undergo.[citation needed] However the meaning of matter used here relates explicitly to substances made of atoms and molecules, disregarding the matter within the atomic nuclei and its nuclear reaction or matter within highly ionized plasmas. Nevertheless the field of chemistry is still, on our human scale, very broad and the claim that chemistry is everywhere is accurate.

[edit] Quantum chemistry

Main article: Quantum chemistry

Some view the birth of quantum chemistry in the discovery of the Schrödinger equation and its application to hydrogen atom in 1926.[citation needed] However, the 1927 article of Walter Heitler and Fritz London[18] is often recognised as the first milestone in the history of quantum chemistry.[citation needed] This is the first application of quantum mechanics to the diatomic hydrogen molecule, and thus to the phenomenon of the chemical bond. In the following years much progress was accomplished by Edward Teller, Robert S. Mulliken, Max Born, J. Robert Oppenheimer, Linus Pauling, Erich Hückel, Douglas Hartree, Vladimir Aleksandrovich Fock, to cite a few.[citation needed]

Still, skepticism remained as to the general power of quantum mechanics applied to complex chemical systems.[citation needed] The situation around 1930 is described by Paul Dirac:[19]

"The underlying physical laws necessary for the mathematical theory of a large part of physics and the whole of chemistry are thus completely known, and the difficulty is only that the exact application of these laws leads to equations much too complicated to be soluble. It therefore becomes desirable that approximate practical methods of applying quantum mechanics should be developed, which can lead to an explanation of the main features of complex atomic systems without too much computation. Hence the quantum mechanical methods developed in the 1930s and 1940s are often referred to as theoretical molecular or atomic physics to underline the fact that they were more the application of quantum mechanics to chemistry and spectroscopy than answers to chemically relevant questions."

In the 1940s many physicists turned from molecular or atomic physics to nuclear physics (like J. Robert Oppenheimer or Edward Teller). In 1951, a milestone article in quantum chemistry is the seminal paper of Clemens C. J. Roothaan on Roothaan equations.[20] It opened the avenue to the solution of the self-consistent field equations for small molecules like hydrogen or nitrogen. Those computations were performed with the help of tables of integrals which were computed on the most advanced computers of the time.[citation needed]

[edit] Molecular biology and biochemistry

By the mid 20th century, in principle, the integration of physics and chemistry was extensive, with chemical properties explained as the result of the electronic structure of the atom; Linus Pauling's book on The Nature of the Chemical Bond used the principles of quantum mechanics to deduce bond angles in ever-more complicated molecules. However, though some principles deduced from quantum mechanics were able to predict qualitatively some chemical features for biologically relevant molecules, they were, till the end of the 20th century, more a collection of rules, observations, and recipes than rigorous ab initio quantitative methods.[citation needed]

This heuristic approach triumphed in 1953 when James Watson and Francis Crick deduced the double helical structure of DNA by constructing models constrained by and informed by the knowledge of the chemistry of the constituent parts and the X-ray diffraction patterns obtained by Rosalind Franklin.[21] This discovery lead to an explosion of research into the biochemistry of life.

In the same year, the Miller-Urey experiment demonstrated that basic constituents of protein, simple amino acids, could themselves be built up from simpler molecules in a simulation of primordial processes on Earth. Though many questions remain about the true nature of the origin of life, this was the first attempt by chemists to study hypothetical processes in the laboratory under controlled conditions.[citation needed]

In 1983 Kary Mullis devised a method for the in-vitro amplification of DNA, known as the polymerase chain reaction (PCR), which revolutionized the chemical processes used in the laboratory to manipulate it. PCR could be used to synthesize specific pieces of DNA and made possible the sequencing of DNA of organisms, which culminated in the huge human genome project.[citation needed]

[edit] Chemical industry

Main article: Chemical industry

The later part of the nineteenth century saw a huge increase in the exploitation of petroleum extracted from the earth for the production of a host of chemicals and largely replaced the use of whale oil, coal tar and naval stores used previously. Large scale production and refinement of petroleum provided feedstocks for liquid fuels such as gasoline and diesel, solvents, lubricants, asphalt, waxes, and for the production of many of the common materials of the modern world, such as synthetic fibers, plastics, paints, detergents, pharmaceuticals, adhesives and ammonia as fertilizer and for other uses. Many of these required new catalysts and the utilization of chemical engineering for their cost-effective production.[citation needed]

In the mid-twentieth century, control of the electronic structure of semiconductor materials was made precise by the creation of large ingots of extremely pure single crystals of silicon and germanium. Accurate control of their chemical composition by doping with other elements made the production of the solid state transistor in 1951 and made possible the production of tiny integrated circuits for use in electronic devices, especially computers, which revolutionized the world.[citation needed]

[edit] See also

[edit] Histories and timelines

[edit] Chemists

listed chronologically:

[edit] Notes

  1. ^ Lucretius (50 BCE). de Rerum Natura (On the Nature of Things). The Internet Classics Archive. Massachusetts Institute of Technology. Retrieved on 2007-01-09.
  2. ^ Simpson, David (29 June 2005). Lucretius (c. 99 - c. 55 BCE). The Internet History of Philosophy. Retrieved on 2007-01-09.
  3. ^ Will Durant (1935), Our Oriental Heritage:

    "Two systems of Hindu thought propound physical theories suggestively similar to those of Greece. Kanada, founder of the Vaisheshika philosophy, held that the world was composed of atoms as many in kind as the various elements. The Jains more nearly approximated to Democritus by teaching that all atoms were of the same kind, producing different effects by diverse modes of combinations. Kanada believed light and heat to be varieties of the same substance; Udayana taught that all heat comes from the sun; and Vachaspati, like Newton, interpreted light as composed of minute particles emitted by substances and striking the eye."

  4. ^ Brock, William H. (1992). The Fontana History of Chemistry. London, England: Fontana Press, 32-33. 
  5. ^ Brock, William H. (1992). The Fontana History of Chemistry. London, England: Fontana Press. 
  6. ^ Derewenda, Zygmunt S. (2007), "On wine, chirality and crystallography", Acta Crystallographica Section A: Foundations of Crystallography 64: 246-258 [247] 
  7. ^ John Warren (2005). "War and the Cultural Heritage of Iraq: a sadly mismanaged affair", Third World Quarterly, Volume 26, Issue 4 & 5, p. 815-830.
  8. ^ Dr. A. Zahoor (1997), JABIR IBN HAIYAN (Jabir), University of Indonesia
  9. ^ Paul Vallely, How Islamic inventors changed the world, The Independent
  10. ^ Will Durant (1980). The Age of Faith (The Story of Civilization, Volume 4), p. 162-186. Simon & Schuster. ISBN 0671012002.
  11. ^ Research Committee of Strasburg University, Imam Jafar Ibn Muhammad As-Sadiq A.S. The Great Muslim Scientist and Philosopher, translated by Kaukab Ali Mirza, 2000. Willowdale Ont. ISBN 0969949014.
  12. ^ G. Stolyarov II (2002), "Rhazes: The Thinking Western Physician", The Rational Argumentator, Issue VI.
  13. ^ Felix Klein-Frank (2001), "Al-Kindi", in Oliver Leaman & Hossein Nasr, History of Islamic Philosophy, p. 174. London: Routledge.
  14. ^ Michael E. Marmura (1965). "An Introduction to Islamic Cosmological Doctrines. Conceptions of Nature and Methods Used for Its Study by the Ikhwan Al-Safa'an, Al-Biruni, and Ibn Sina by Seyyed Hossein Nasr", Speculum 40 (4), p. 744-746.
  15. ^ Robert Briffault (1938). The Making of Humanity, p. 196-197.
  16. ^ Farid Alakbarov (Summer 2001). A 13th-Century Darwin? Tusi's Views on Evolution, Azerbaijan International 9 (2).
  17. ^ a b Pullman, Bernard (2004). The Atom in the History of Human Thought. USA: Oxford University Press Inc. 
  18. ^ W. Heitler and F. London, Wechselwirkung neutraler Atome und Homöopolare Bindung nach der Quantenmechanik, Z. Physik, 44, 455 (1927).
  19. ^ P.A.M. Dirac, Quantum Mechanics of Many-Electron Systems, Proc. R. Soc. London, A 123, 714 (1929).
  20. ^ C.C.J. Roothaan, A Study of Two-Center Integrals Useful in Calculations on Molecular Structure, J. Chem. Phys., 19, 1445 (1951).
  21. ^ Watson, J. and Crick, F., "Molecular Structure of Nucleic Acids" Nature, April 25, 1953, p 737–8

[edit] References

[edit] External links